Genetic architecture of the inflammatory bowel diseases across East Asian and European ancestries
Z Liu, R Liu, H Gao, S Jung, X Gao, R Sun, X Liu… - Nature Genetics, 2023 - nature.com
… To date, most IBD genetic associations were derived from individuals of European (EUR)
ancestries. Here we report the largest IBD study of individuals of East Asian (EAS)
ancestries, including 14,393 cases and 15,456 controls. We found 80 IBD loci in EAS alone
and 320 when meta-analyzed with ~370,000 EUR individuals (~30,000 cases), among
which 81 are new. EAS-enriched coding variants implicate many new IBD … Consortium (IIBDGC),
and 5,671 cases and 303,191 controls from FinnGen 18 , an EUR population with a unique …
ancestries. Here we report the largest IBD study of individuals of East Asian (EAS)
ancestries, including 14,393 cases and 15,456 controls. We found 80 IBD loci in EAS alone
and 320 when meta-analyzed with ~370,000 EUR individuals (~30,000 cases), among
which 81 are new. EAS-enriched coding variants implicate many new IBD … Consortium (IIBDGC),
and 5,671 cases and 303,191 controls from FinnGen 18 , an EUR population with a unique …
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